Substituted pyrimidinyl-amines as protein kinase inhibitors

Details Substituted pyrimidinyl-amines as protein kinase inhibitors Substituted pyrimidinyl-amines as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) C07D 239/42 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 491/113 (2006.01)

Patent

CA 2698511

The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.

La présente invention porte sur de nouvelles pyrimidinyl-amines substituées qui sont utiles comme inhibiteurs de la protéine kinase, en particulier des kinases N-terminales c-Jun (JNK), et sur des compositions pharmaceutiques de celles-ci et sur des procédés d'utilisation de celles-ci pour traiter des états sensibles à l'inhibition de la voie JNK.

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