Substituted pyrimidodiazepines useful as plk1 inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 471/18 (2006.01) A61K 31/551 (2006.01) A61K 31/5517 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01) C07D 487/18 (2006.01)

Patent

CA 2680757

The present invention provides PLK1 inhibitor compounds of formula (I). Useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas.

La présente invention concerne des composés inhibiteurs de PLK1 de formule (I). Les composés selon l'invention sont utiles pour le traitement ou le contrôle de troubles de la prolifération cellulaire, notamment de troubles oncologiques. Ces composés et des formulations contenant de tels composés peuvent être utiles pour le traitement ou le contrôle de tumeurs solides, telles que par exemple des tumeurs du sein, du colon, du poumon et de la prostate, ainsi que d'autres maladies oncologiques telles que les lymphomes non hodgkiniens.

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