Substituted pyrrol-1-ylphenyldihydropyridazinones, their...

Details Substituted pyrrol-1-ylphenyldihydropyridazinones, their... Substituted pyrrol-1-ylphenyldihydropyridazinones, their...

C - Chemistry, Metallurgy

07

D

167/224, 260/264

C07D 403/12 (2006.01) A61K 31/50 (2006.01) C07D 403/10 (2006.01)

Patent

CA 1293254

ABSTRACT OF THE DISCLOSURE: Disclosed are new substituted pyrrol-1-ylphenyl- dihydropyridazinones of the formula Image where R1 is hydrogen, methyl or hydroxymethyl, R2 is hydrogen or methyl, or R1 and R2 together form a radical -(CH2)m-, in which m is an integer from 1 to 4, R3, R4 and R5, independently of one another are each hydrogen or C1-C6- alkyl, R is hydrogen or, together with R1, forms a radical -(CH2)n-, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or -together form a bond, D is hydrogen, C1-C6-alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R3 is hydrogen, one or both of the radicals R4 and R5 are C1-C6- alkyl or D is C1-C6-alkyl or phenyl. These compounds are useful as antihypertensives and for the treatment of thrombotic disorders, cardiac insufficiency and disorders accompanied by pathological increase in the secretion of gastric acid, such as gastric and duodenal ulcers.

524680

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