C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/233, 260/299
C07D 487/04 (2006.01) A61K 31/40 (2006.01) C07D 207/30 (2006.01) C07D 207/323 (2006.01) C07D 207/337 (2006.01)
Patent
CA 2016501
The invention concerns substituted pyrrole compounds and their applications in pharmacy. The compounds of the invention are potent inhibitors of lipoxygenase and cyclo- oxygenase and therefore are suitable to treat the set of rheumatic illnesses and to prevent allergically induced ailments. The compounds have the general formula: Image where R1 denotes a C1-C12 alkyl group, R2 denotes a hydrogen atom or a C1-C12 alkyl group, or R1 and R2 together with the carbon atom and the nitrogen atom to which they are bound form a ring of 5 to 8 links which may contain a sulfur heteroatom or a carbonyl group and may be substituted with one or two C1-C4 alkyl groups, each time two of the residues R3, R4 and R5 independently from one another represent a hydrogen atom, a C5- C8 cycloalkyl group, a C1-C12 alkyl group or an aryl group which may be substituted by one or two residues selected from a halogen atom, a nitro-, a C1-C4 alkoxy-, a hydroxy-, a C1-C4 alkyl- or phenoxy-group, and where the third of the residues R3, R4 and R5 denotes -CHO, -CO2H, -COSC1-C4-alkyl or A-X, with A being a straight- chain or a branched C1-C8 alkylene group which may be interrupted by an oxygen heteroatom or a carbonyl group or being a C2-C8 alkenylene group, X being CO2H, SO3H, CHO, OH or as well as their pharmaceutically compatible salts and esters, for pharmaceutical applications.
Dannhardt Gerd
Lehr Matthias
Steindl Ludwig
Dannhardt Gerd
Merckle G.m.b.h.
Smart & Biggar
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