C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 471/10 (2006.01)
Patent
CA 2160462
The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein. The compound has the general structure Image
La présente invention concerne des pyrrolidinyl-3-yl-alkyl-pipéridines substituées, leurs stéréoisomères et des sels de ces composés utiles en pharmacie, et des procédés de préparation de ceux-ci. Les composés de la présente invention sont utiles à cause de leur activité pharmacologique telle que l'antagonisme des tachykinines, en particulier l'antagonisme de la substance P et de la neurokinine A, et de substances similaires. Les composés exhibant un antagonisme des tachykinines sont indiqués pour les symptômes associés aux inflammations neurogènes et aux autres maladies décrites. Ce composé a la structure générale Image .
Burkholder Timothy P.
Kudlacz Elizabeth M.
Le Tieu-Binh
Maynard George D.
Aventis Inc.
Osler Hoskin & Harcourt Llp
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