C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/270
C07D 207/26 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 451/02 (2006.01)
Patent
CA 1255664
Abstract The invention relates to new substituted pyrrolidinones of general formula (I) (I) Image wherein R1 represents a phenyl group optionally mono- or di-substituted by a methyl, methoxy or trifluoromethyl group, a fluorine, chlorine or bromine atom, or a pyridyl group; R2 represents hydrogen or a straight- or branched-chain alkyl group with 1-4 carbon atoms; R3 represents a straight- or branched-chain alkyl group with 1-3 carbon atoms, a hydroxyalkyl group with 2-3 carbon atoms, a phenyl group optionally mono- or di-substituted by a chlorine or bromine atom, a methyl, methoxy or cyclohexyl group or a dialkylaminoalkyl group, wherein each alkyl group contains from 1-3 carbon atoms; R4 represents hydrogen or a straight- or branched-chain alkyl group with 1-3 carbon atoms or R3 and R4 together with the nitrogen atom to which they are both attached represent a piperidine, morpholine or piperazine ring, wherein the rings may be substituted by one or two methyl groups and the piperazine ring may also carry a phenyl, chlorophenyl or benzyl group at the nitrogen atom in the 4-position, or they may represent a nortropanyl group; and physiologically acceptable acid addition salts of compounds of formula (I) which have a basic function in the molecule. The invention also relates to processes for preparation of these compounds and pharmaceutical compositions containing them. The new compounds have proved effective in animal trials in alleviating or remedying conditions of restricted cerebral performance.
482660
Ensinger Helmut
Hinzen Dieter
Kuhn Franz J.
Lehr Erich
Schneider Claus
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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