C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 471/00 (2006.01) C07D 487/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2485527
The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder, Formula (I), wherein R is selected from the group consisting of Ra~ -C1-8alkyl-Ra~ -C2-8alkenyl-Ra~ -C2-8alkynyl-Ra and cyano; Ra is selected from the group consisting of cycloalkyl, heterocyclyl, aryl and heteroaryl;
La présente invention concerne de nouveaux composés substitués de la pyrroline utilisés comme inhibiteurs de la kinase, et des méthodes de traitement ou d'amélioration d'un trouble induit par la kinase. Dans lesdits composés, R est sélectionné dans le groupe constitué par R¿a'? -alkyle C¿1-8?-R¿a'? -alcényle C¿2-8?-R¿a'? -alkynyle C¿2-8?-R¿a? and cyano; R¿a? est sélectionné dans le groupe constitué par cycloalkyle, hétérocyclyle, aryle and hétéroaryle.
Conway Bruce
Demarest Keith
Kuo Gee-Hong
Maryanoff Bruce E.
Mccomsey David F.
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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