Substituted pyrrolines as kinase inhibitors

Details Substituted pyrrolines as kinase inhibitors Substituted pyrrolines as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4025 (2006.01) A61K 31/404 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2488602

The present invention is directed to novel substituted pyrroline compounds of Formula (I) wherein R1 is selected from the group consisting of a pyridinyl- R5, pyrimidinyl-R5, pyrazinyl-R5, furyl-R5, thienyl-R5, benzofuryl-R5, benzothienyl-R5, quinolinyl-R5 and isoquinolinyl-R5 ring attached to the indole nitrogen atom via a ring carbon atom;useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder such as cardiovascular, inflammatory, immunological, dermatological, oncological, CNS disorders and diabetes.

L'invention porte sur des nouveaux composés de pyrroline substitués représentés par la formule (I) dans laquelle R?1¿ est choisis dans le groupe noyau de pyridinyl-R5, pyrimidinyl-R5, pyrazinyl-R5, furyl-R5, thiényl-R5, benzofuryl-R5, benzothiényl-R5, quinolinyl-R5 et isoquinolinyl-R5 lié à l'atome d'azote indole par un atome de carbone sur la chaîne ; utiles en tant qu'inhibiteurs de double kinase. L'invention porte aussi sur des procédés de fabrication de ces composés et sur des méthodes de traitement ou d'amélioration d'un trouble induit par kinase ou double kinase tel que les troubles cardio-vasculaires, inflammatoires immunologiques, dermatologiques, oncologiques, les troubles SNC et le diabète.

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