Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Details Substituted pyrrolo-pyrazole derivatives as kinase inhibitors Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4162 (2006.01) A61P 17/00 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07D 231/00 (2006.01) C07D 487/00 (2006.01)

Patent

CA 2508069

Compounds represented by formula (Ia) or (lb) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.

L'invention concerne des composés représentés par la formule (Ia) ou (Ib), dans lesquelles R et R¿1? sont tels que définis dans la description, ainsi que des sels pharmaceutiquement acceptables de ces composés. Lesdits composés sont utiles pour traiter des troubles caractérisés par une prolifération cellulaire, tels que le cancer, associés à une altération de l'activité kinase dépendante du cycle cellulaire.

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