Substituted pyrrolones as allosteric modulators of glucokinase

Details Substituted pyrrolones as allosteric modulators of glucokinase Substituted pyrrolones as allosteric modulators of glucokinase

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/465 (2006.01) A61P 3/10 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2627813

The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated disorders. More particularly, the compounds of the present invention are glucokinase modulators useful for treating disorders including, but not limited to, type II diabetes.

L'invention concerne des composés de formule générale (I), des procédés de préparation de ces composés, des compositions, des intermédiaires et des dérivés de ceux-ci et des méthodes de traitement de troubles à médiation assurée par la glucokinase. Plus particulièrement, les composés de l'invention sont des modulateurs de glucokinase servant à traiter les troubles de type, entre autres, diabète de type II.

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