C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2689161
Provided herein are substituted pyrrolopyridine heterocycles and substituted pyrazolopyridine heterocycles, pharmaceutical compositions comprising said heterocycles and methods of using said heterocycles in the treatment of disease. The heterocycles disclosed herein function as kinase modulators and have utility in the treatment of diseases such as cancer, allergy, asthma, inflammation, obstructive airway disease, autoimmune diseases, metabolic disease, infection, CNS disease, brain tumor, obesity, asthma, hematological disorder, degenerative neural disease, cardiovascular disease, or disease associated with angiogenesis, neovascularization, or vasculogenesis.
L'invention concerne des hétérocycles de pyrrolopyridine substitués et des hétérocycles de pyrazolopyridine substitués, des compositions pharmaceutiques comprenant lesdits hétérocycles et des procédés d'utilisation desdits hétérocycles dans le traitement de maladies. Les hétérocycles divulgués ici fonctionnent comme des modulateurs de kinase et sont utiles dans le traitement de maladies telles que le cancer, les allergies, l'asthme, les inflammations, le syndrome obstructif, les maladies auto-immunitaires, les maladies métaboliques, les infections, les maladies du système nerveux central, les tumeurs du cerveau, l'obésité, les troubles hématologiques, les maladies neurales dégénératives, les maladies cardiovasculaires ou les maladies associées à une angiogenèse, à une néovascularisation ou à une vasculogenèse.
Blaney Jeffrey M.
Gosberg Andreas
Gradl Stefan N.
Hirst Gavin
Hopkins Stephanie A.
Sgx Pharmaceuticals Inc.
Smart & Biggar
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