Substituted quinazoline derivatives and their use as...

Details Substituted quinazoline derivatives and their use as... Substituted quinazoline derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/505 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2299632

This invention provides compounds of formula (1) Image wherein X is a C3-C7 substituted or unsubstituted cycloalkyl, pyridinyl, pyrimidinyl or phenyl rings, R1, R3 and R4 are independently hydrogen, halogen and specified organic radicals of between 1 and 12 carbon atoms in length, and R2 is chosen from various unsaturated acyl groups. The novel compounds are useful as tyrosine kinase inhibitors for the treatment of cancer and certain kidney diseases, such as polycystic kidney disease.

Cette invention concerne des composés de la formule (1) dans laquelle X représente C3-7 cycloalkyle, pyridinyle, pyrimidinyle ou phényle éventuellement substitué et décrit dans la revendication 1, R1, R3 et R4 sont choisis dans les groupes énumérés dans la revendication 1. R2 est choisi parmi plusieurs groupes acyles insaturés énumérés dans la revendication 1, certains composés n'étant pas revendiqués. Ces composés jouent le rôle d'inhibiteur de la la tyrosine kinase pour le traitement du cancer et de certaines maladies des reins telles que la maladie polykystique des reins.

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