Substituted quinazolines as pde10 inhibitors

Details Substituted quinazolines as pde10 inhibitors Substituted quinazolines as pde10 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/519 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2641670

The invention pertains to substituted quinazoline compounds of structures (I) and (II) that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds which are selective inhibitors of PDE-10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom. (I, II).

La présente invention concerne des quinazolines substituées qui jouent le rôle d'inhibiteurs efficaces de phosphodiestérase (PDE). La présente invention concerne également des composés qui sont des inhibiteurs sélectifs de la PDE-10. La présente invention concerne également des intermédiaires de synthèse de tels composés; des compositions pharmaceutiques comprenant de tels composés; et l'emploi de tels composés dans des méthodes de traitement de certains troubles du système nerveux central (SNC) ou d'autres troubles. La présente invention concerne de plus des méthodes de traitement de troubles neurodégénératifs et psychiatriques, par exemple la psychose et les troubles dont l'un des symptômes est une déficience cognitive.

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