Substituted quinobenzoxazine analogs and methods of using...

Details Substituted quinobenzoxazine analogs and methods of using... Substituted quinobenzoxazine analogs and methods of using...

A - Human Necessities

61

K

A61K 31/5383 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) C07D 498/06 (2006.01)

Patent

CA 2575547

The present invention relates to quinobenzoxazines analogs having the general formula: (1) or (2) and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein V, A, X, Z, W, U and R5 are substituents. The present invention also relates to methods for using such compounds, such as in screening and for inducing apoptosis.

L'invention concerne des analogues de quinobenzoxazines présentant la formule générale (1) ou (2), ainsi que des sels pharmaceutiquement acceptables, des esters, et des promédicaments de ces composés. Dans lesdites formules, V, A, X, Z, W, U et R5 sont des substituants. Cette invention se rapporte en outre à des procédés d'utilisation de ces composés, par exemple pour détecter et induire l'apoptose.

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