Substituted quinoline ccr5 receptor antagonists

Details Substituted quinoline ccr5 receptor antagonists Substituted quinoline ccr5 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 215/46 (2006.01) A61K 31/4706 (2006.01) A61K 31/4709 (2006.01) A61P 31/18 (2006.01) C07D 215/48 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2489560

The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b), enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated disorders employing such compounds.

La présente invention concerne des antagonistes du récepteur CCR5 représentés par la formule (1a) ou la formule (1b), dans lesquelles R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et R?7¿ sont tels que définis dans la description, ainsi que des énantiomères, des diastéréomères, des sels et des solvates de ceux-ci. L'invention concerne en outre une méthode de traitement de troubles à médiation par le CCR5 au moyen de ces composés.

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