Substituted quinoline derivatives as mitotic kinesin inhibitors

Details Substituted quinoline derivatives as mitotic kinesin inhibitors Substituted quinoline derivatives as mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 215/12 (2006.01) A61K 31/47 (2006.01) A61P 35/00 (2006.01) C07D 215/18 (2006.01)

Patent

CA 2564215

The present invention relates to new substituted quinoline compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds as kinesin spindle protein inhibitors. The compounds of the invention have the following general formula (I).

Cette invention concerne de nouveaux composés de quinolinone substituée ainsi que ses sels, esters et promédicaments acceptables d~un point de vue pharmaceutique, des préparations à base de ces nouveaux composés ainsi que des entraîneurs acceptables d~un point de vue pharmaceutique, et des utilisations de ces nouveaux composés en tant qu~inhibiteurs de la protéine filamenteuse de kinésine. Les composés de cette invention ont la formule générale suivante (I).

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