Substituted quinolines for use as vegf inhibitors

Details Substituted quinolines for use as vegf inhibitors Substituted quinolines for use as vegf inhibitors

C - Chemistry, Metallurgy

07

D

C07D 215/44 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2762232

A compound of formula (I), as well as pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising a therapeutically effective amount of the compounds. The compound is useful in treatment of cancer, diabetic retinopathy, age-related macular degeneration, inflammation, stroke, ischemic myocardium, atherosclerosis, macular edema and psoriasis.

L'invention porte sur un composé de formule (I), ainsi que sur des sels pharmaceutiquement acceptables de celui-ci et sur des compositions pharmaceutiquement acceptables comprenant une quantité thérapeutiquement efficace des composés. Le composé est utile dans le traitement du cancer, d'une rétinopathie diabétique, d'une dégénérescence maculaire liée à l'âge, d'une inflammation, d'un accident vasculaire cérébral, d'un myocarde ischémique, de l'athérosclérose, d'un dème maculaire et du psoriasis.

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