Substituted quinolone derivatives and pharmaceuticals...

Details Substituted quinolone derivatives and pharmaceuticals... Substituted quinolone derivatives and pharmaceuticals...

C - Chemistry, Metallurgy

07

D

C07D 215/54 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 215/42 (2006.01) C07D 215/44 (2006.01) C07D 215/46 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2246118

Substituted quinolone derivatives represented by the following formula: (see fig. I) wherein R1 represents a substituted or unsubstituted (hetero)aryl group, R2 represents H or an alkoxycarbonyl, substituted aminocarbonyl, cyano or like group, and R3 and R4 each independently represent H or a substituted alkyl, aryl, amino or like group, and salts thereof; pharmaceuticals containing the same. These derivatives and salts have excellent anti-ulcer activities.

Dérivés de substitution de la quinolone, représentés par la formule suivante (voir fig. I), où : R1 représente un groupe (hétéro)aryle avec ou sans substitution; R2 représente H ou un alcoxycarbonyle, un aminocarbonyle avec substitution, cyano ou un groupe de même type; R3 et R4 représentent chacun indépendamment H ou un amino, aryle ou alkyle avec substitution, ou un groupe de même type. L'invention porte aussi sur leurs sels et sur des composés pharmaceutiques qui en renferment. Ces dérivés et sels possèdent d'excellentes propriétés antiulcéreuses.

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