Substituted ring fused azines and their use in cancer therapy

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 407/04 (2006.01) A61K 31/4706 (2006.01) A61K 31/517 (2006.01) C07D 215/44 (2006.01) C07D 215/46 (2006.01) C07D 217/22 (2006.01) C07D 239/86 (2006.01) C07D 239/91 (2006.01) C07D 239/94 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 407/06 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2648323

The present invention relates to substituted ring fused azines and methods of using said compounds in treating cancers. More specifically, the present invention relates to the preparation of 4-alkyl-2-(heterocyclic)-azines and their use as cancer agents or drugs for cancer therapy. The compounds of the invention display favourable in vivo and in vitro activity against selected cancers.

La présente invention concerne des azines à noyau condensées et substituées et les procédés d'utilisation desdits composés pour le traitement de cancers. Plus spécifiquement, la présente invention concerne la préparation de 4-alkylazines hétérocycliques en position 2 et leur utilisation en tant qu'agents ou médicaments anti-cancéreux dans une thérapie anti-cancéreuse. Les composés de l'invention présentent une activité avantageuse in vivo et in vitro contre certains cancers.

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