Substituted silyl alcohols

Details Substituted silyl alcohols Substituted silyl alcohols

C - Chemistry, Metallurgy

07

F

C07F 7/08 (2006.01) C07F 9/24 (2006.01) C07H 1/02 (2006.01)

Patent

CA 2107910

2107910 9222557 PCTABS00018 Novel silyl alcohols having bulky substituents bonded to the silicon, and the silyl group attached to a carbon include the preferred 2-silyl-ethan-1-ols. A method for synthesizing silyl substituted alcohols includes hydrosilation of a vinylic ester, especially vinyl acetate, followed by hydrolysis in mild base. The silyl alcohols are useful in preparing phosphorylating reagents for phosphorylating an oligonucleotide. The phosphorylated intermediate bearing the silyl group may be separated from failure product on the basis of bulky substituents on the silyl protecting group, which is later removed, e.g. by fluoride ion.

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