Substituted spiro compounds for the treatment of inflammation

Details Substituted spiro compounds for the treatment of inflammation Substituted spiro compounds for the treatment of inflammation

C - Chemistry, Metallurgy

07

C

C07C 317/14 (2006.01) A61K 31/10 (2006.01) A61K 31/18 (2006.01) A61K 31/275 (2006.01) A61K 31/36 (2006.01) A61K 31/44 (2006.01) C07C 311/16 (2006.01) C07C 311/29 (2006.01) C07C 317/22 (2006.01) C07C 323/64 (2006.01) C07C 323/65 (2006.01) C07D 213/04 (2006.01) C07D 213/34 (2006.01) C07D 213/61 (2006.01) C07D 213/70 (2006.01) C07D 317/56 (2006.01) C07D 405/08 (2006.01)

Patent

CA 2182950

A class of substituted spiro compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (III), wherein n is a number selected from 0, 1 and 2; wherein R6 is selected from hydrido and halo; wherein R7 is selected from hydrido and halo; wherein R8 is selected from hydrido, halo, lower alkyl, lower alkoxy, lower haloalkyl, lower haloalkoxy, and hydroxyl; wherein R9 is selected from hydrido, halo, and lower alkyl; or wherein R8 and R9 together form methylenedioxy; and wherein R11 is selected from lower alkyl and amino; or a pharmaceutically-acceptable salt thereof.

L'invention décrit une classe de composés spiranniques substitués utilisés dans le traitement des inflammations et des troubles inflammatoires. Les composés d'un intérêt particulier sont définis par la formule (III), dans laquelle n est un nombre sélectionné parmi 0, 1 et 2; R?6¿ est sélectionné parmi hydrido et halo; R?7¿ est sélectionné parmi hydrido et halo; R?8¿ est sélectionné parmi hydrido, halo, alkyle inférieur, alcoxy inférieur, haloalkyle inférieur, haloalcoxy inférieur et hydroxyle; R?9¿ est sélectionné parmi hydride, halo et alkyle inférieur ou R?8¿ et R?9¿ forment ensemble le méthylènedioxy; et R?11¿ est sélectionné parmi alkyle inférieur et amino; ou un sel pharmaceutiquement acceptable de ces composés.

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