Substituted spirocyclic amines useful as antidiabetic compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 471/10 (2006.01) A61K 31/435 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2759651

Substituted spirocyclic amines of structural formula I are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, metabolic syndrome, depression, and anxiety.

La présente invention concerne des amines spirocycliques substituées de formule structurale I qui sont des antagonistes sélectifs du récepteur de sous-type de somatostatine 5 (SSTR5) et sont utiles pour le traitement, la gestion ou la prévention de troubles sensibles à l'antagonisme de SSTR5, tels que le diabète de type 2, l'insulinorésistance, les troubles lipidiques, l'obésité, l'athérosclérose, le syndrome métabolique, la dépression, et l'anxiété.

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