C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/435 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2759651
Substituted spirocyclic amines of structural formula I are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, metabolic syndrome, depression, and anxiety.
La présente invention concerne des amines spirocycliques substituées de formule structurale I qui sont des antagonistes sélectifs du récepteur de sous-type de somatostatine 5 (SSTR5) et sont utiles pour le traitement, la gestion ou la prévention de troubles sensibles à l'antagonisme de SSTR5, tels que le diabète de type 2, l'insulinorésistance, les troubles lipidiques, l'obésité, l'athérosclérose, le syndrome métabolique, la dépression, et l'anxiété.
Aster Susan D.
Duffy Joseph L.
Liang Gui-Bai
Shao Patrick
Ye Feng
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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