Substituted steroid-spiro-oxazolidinone derivatives and a...

Details Substituted steroid-spiro-oxazolidinone derivatives and a... Substituted steroid-spiro-oxazolidinone derivatives and a...

C - Chemistry, Metallurgy

07

J

260/18

C07J 43/00 (2006.01)

Patent

CA 1118767

ABSTRACT OF THE DISCLOSURE The invention relates to new steroid-spiro-oxazolidinone derivatives of the general formula (I), Image (I) wherein R1 stands for hydrogen or a methyl group, R2 stands for a C1-4 alkyl group, R3 stands for hydrogen, a C1-4 alkyl group or a C2-4 alkenyl group, Z1 and Z2 stand each for a hydrogen atom or together for a second valence bond, or Z1 stands for a hydrogen atom and Z2 is an R4-S- group, Z3 and Z4 stand each for a hydrogen atom or together for a second valence bond, or Z3 stands for a hydrcgen atcm and Z2 is an R4-S- group, but at least one of the pairs Z1 - Z2 and Z3 - Z4 represents a hydrogen atom and an R4-S- group, and R4 represents a hydrogen atom or an alkyl, alkenyl, aralkyl or acyl group of up to 7 carbon atoms, with the proviso that when Z1 and Z2 stand together for a valence bond, or Z1 represents a hydrogen atom and Z2 an R4-S- group then R1 may stand only for a methyl group, and pharmaceutical compositions containing the same, furthermore to a process for the preparation thereof. The new compounds of the general formula (I), which are valuable antialdosterone-type diuretic agents, are prepared according to the invention by reacting the respective vinylene steroids with a thiol of the general formula R4-SH.

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