Substituted stilbenes as glucose uptake enhancers

Details Substituted stilbenes as glucose uptake enhancers Substituted stilbenes as glucose uptake enhancers

C - Chemistry, Metallurgy

07

C

C07C 235/56 (2006.01) A61K 31/196 (2006.01) A61K 31/245 (2006.01) A61P 3/10 (2006.01) C07C 233/81 (2006.01)

Patent

CA 2411340

The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, methods of treatment administering these compounds to mammalian hosts, and processes for their preparation. Specifically, the invention relates to a means to enhance insulin-dependent glucose uptake. More specifically, the invention concerns compounds and pharmaceutical compositions that activate the insulin receptor kinase, which leads to increased sensitivity to insulin and an increase in glucose uptake, as well as processes for the preparation of the compounds. The invention also specifically concerns methods for treating humans with hyperglycemia, especially for the treatment of Type II diabetes.

La présente invention concerne des composés chimiques, des compositions pharmaceutiques contenant ces composés, des méthodes de traitement par administration de ces composés à des hôtes mammifères, et des méthodes de préparation desdits composés. Elle concerne notamment un moyen d'améliorer l'absorption de glucose dans des situations d'insulino-dépendance. L'invention concerne en particulier des composés et des compositions pharmaceutiques qui activent le récepteur kinase de l'insuline et augmentent la sensibilité à l'insuline et l'absorption de glucose, ainsi que des méthodes de préparation de ces composés. Plus particulièrement, l'invention concerne des méthodes de traitement d'humains atteints d'hyperglycémie, notamment des méthodes de traitement du diabète non insulino-dépendant.

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