C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 215/36 (2006.01) C07D 217/02 (2006.01) C07D 239/88 (2006.01) C07D 277/62 (2006.01) C07D 401/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2080128
43 ABSTRACT Disclosed is a substituted sulfonamide derivative represented by formula (I) or a pharmaceutically ac- ceptable acid addition salt thereof Image (I) wherein A represents a hydrogen atom or an alkyl group, G represents a methylene group or an alkylene group, Q1 represents an ethylene group, Q2 represents an ethylene group or a trimethylene group, E represents an alkyl group or a group represented by a formula selected from formula (II-a) and (II-b) - G - J - Z (II-a), - G - Z (II-b) wherein G is as defined above, J represents an oxygen atom, a sulfur atom or a nitrogen atom, and Z represents an aryl group unsubstituted or sub- stituted with an alkyl group or an alkoxy group, or a heterocyclic group, an d X represents a quinolyl group, an isoqulnolyl group, a benzothiazolyl group or a quinazolin-4-on group. The substituted sulfonamide derivative and pharmaceuti- cally acceptable acid addition salt thereof affect the bronchial smooth muscle of a mammal, and are useful as an active ingredient of a pharmaceutical composition for the prevention and treatment of respiratory dis- eases, such as asthma.
Asano Toshio
Kajihara Akiro
Asahi Kasei Kogyo Kabushiki Kaisha
Goudreau Gage Dubuc
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