Substituted tetracycline compounds

Details Substituted tetracycline compounds Substituted tetracycline compounds

C - Chemistry, Metallurgy

07

D

C07D 207/50 (2006.01) A61K 31/65 (2006.01) A61P 31/04 (2006.01) A61P 33/06 (2006.01) C07C 237/26 (2006.01) C07D 231/12 (2006.01) C07D 239/20 (2006.01) C07D 241/12 (2006.01) C07D 261/02 (2006.01) C07D 261/04 (2006.01) C07D 263/32 (2006.01) C07D 265/02 (2006.01)

Patent

CA 2673466

The present invention pertains, at least in part, to a substituted tetracycline compound of Formula (I): wherein X is CHC(R13VY), CR6 R6, C=CR6 R6, S, NR6, or O; E is NR7dR7.beta., OR7f or (CH2)o.iC(=W)WR7s; W is O, S, NR711 or CR75R7*; W is O, S or NR7*; These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.

La présente invention porte, au moins en partie, sur de nouveaux composés de tétracycline substituée. Ces composés de tétracycline peuvent être utilisés pour traiter de nombreux états sensibles aux composés de tétracycline, tels que les infections bactériennes et les néoplasmes.

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