Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as...

Details Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as... Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as...

C - Chemistry, Metallurgy

07

D

C07D 251/08 (2006.01) A61K 31/53 (2006.01)

Patent

CA 2271728

This invention provides compounds of formula (1) having the structure wherein R1, R2, R3, R4, and R5 are each independently, hydrogen, halogen, alkyl, cycloalkyl, alkenyl, alkynyl, phenylalkyl, alkoxy, aryloxy, fluoroalkoxy, trifluoromethyl, alkylthio, alkylsulfony, -SCF3, nitro, alkylamino, or dialkylamino; R6 is hydrogen, alkyl, cycloalkyl, or arylalkyl; and R7 is alkyl, cycloalkyl, or arylalkyl or a pharmaceutically acceptable salt thereof which are useful as antiatherosclerotic agents.

La présente invention concerne des composés représentés par la structure de la formule générale (1) ou l'un de leurs sels pharmaceutiquement admis. Dans cette formule, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont chacun indépendamment hydrogène, halogène, alkyl, cycloalkyl, phénylalkyl, alcoxy, aryloxy, fluoroalcoxy, trifluorométhyl, alkylthio, alkylsulfonyl, -SCF¿3?, nitro, alkylamino ou dialkylamino. R?6¿ est hydrogène, alkyl, cycloalkyl ou arylalkyl. Enfin, R?7¿ est alkyl, cycloalkyl, ou arylalkyl. Ces composés conviennent particulièrement comme agents anti-athéroscléreux.

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