Substituted tetrahydro-2h-isoquinolin-1-one derivatives,...

Details Substituted tetrahydro-2h-isoquinolin-1-one derivatives,... Substituted tetrahydro-2h-isoquinolin-1-one derivatives,...

C - Chemistry, Metallurgy

07

D

C07D 217/24 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61P 9/00 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2570942

The invention relates to compounds of general formula (I), the designations of the substituents R1, R2, Ar and X being cited in the description, and to the physiologically compatible salts thereof. The invention also relates to a method for producing said compounds, and to the use thereof as medicaments. The inventive compounds are poly(ADP-ribose)polymerase (PARP) inhibitors.

L'invention concerne des composés de formule générale (I), ainsi que leurs sels physiologiquement acceptables. Dans ladite formule (I), les substituants R1, R2, Ar et X sont tels que définis dans la description. Cette invention concerne en outre un procédé de production de ces composés, et leur utilisation en tant que médicaments. Les composés selon l'invention sont des inhibiteurs de la poly(ADP-ribose)polymérase (PARP).

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