C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/179, 260/251
C07D 213/46 (2006.01) C07C 43/253 (2006.01) C07C 45/62 (2006.01) C07C 45/63 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 45/71 (2006.01) C07C 45/74 (2006.01) C07C 49/747 (2006.01) C07C 49/755 (2006.01) C07D 213/30 (2006.01) C07D 215/14 (2006.01) C07D 215/20 (2006.01) C07D 215/233 (2006.01) C07D 215/38 (2006.01) C07D 311/22 (2006.01) C07D 313/08 (2006.01) C07D 335/02 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 405/14
Patent
CA 1335451
Disclosed are substituted tetralins, chromans and related compounds of the formula: Image ---(I) (wherein n is 0 or 1; m is 0, 1, 2 or 3; X is CH2, O, S, SO, SO2, NH or N(C1-C4)alkyl; X1 is CH2, O, S, SO or SO2; Y and Y1 together form CO or Y is H and Y1 is OH or acyloxy; Z is lower alkylene; Z1 is CH or N; R1 is an optionally substituted N-containing heterocyclic ring such as pyridyl, quinolyl, isoquinolyl, pyridazinyl, cinnolyl, phthalazinyl, pyrimidinyl, quinazolyl, pyrazinyl, quinoxalinyl etc.; and R1 is an optionally substituted aromatic carbocyclic or heterocyclic ring such as phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, pyridazinyl, cinnolinyl) which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals; pharmaceutical compositions thereof; and intermediates useful in the synthesis thereof.
580349
Eggler James Frederick
Marfat Anthony
Melvin Lawrence Sherman Jr.
Limited Pfizer
Smart & Biggar
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