Substituted thiazoles and oxazoles that modulate ppar activity

Details Substituted thiazoles and oxazoles that modulate ppar activity Substituted thiazoles and oxazoles that modulate ppar activity

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 3/06 (2006.01) C07D 277/26 (2006.01)

Patent

CA 2478164

This invention discloses compounds of structures (1) and (2) that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.

L'invention concerne des composés de structures (1) et (2) modifiant l'activité de PPAR. L'invention concerne également des sels pharmaceutiquement acceptables de ces composés, des compositions pharmaceutiquement acceptables comprenant ces composés ou leurs sels, ainsi que des méthodes d'utilisation desdits composés comme agents thérapeutiques destinés à traiter ou prévenir l'hyperlipidémie et l'hypercholestérolémie chez un mammifère. La présente invention se rapporte en outre à des procédés de fabrication des composés susmentionnés.

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