C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01)
Patent
CA 2314967
A hydrate of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine- 2,4-dione, maleic acid salt, characterised in that it: (i) comprises water in the range of from 0.3 to 0.6 molar equivalents; and (ii) provides an infra red spectrum containing peaks at 1757, 1331, 1290, 1211 and 767 cm-1; and/or (iii) provides a Raman spectrum containing peaks at 1758, 1610, 1394, 1316 and 1289 cm-1; and/or (iv) provides a solid state nuclear magnetic resonance spectrum containing chemical shifts substantially as set out in Table I herein; and/or (v) provides an X-ray powder diffraction (XRPD) pattern substantially as set out in Figure IV herein; a process for the preparation of such a compound, a pharmaceutial composition containing such a compound and the use of such a compound or composition in medicine.
L'invention porte sur un hydrate, sel de l'acide maléïque, de formule 5-[4-[2-(N-méthyl-N-(2-pyridyl)amino)éthoxy]benzyl]thiazolidine-2,4-dione, caractérisé en ce qu'il: (i) comporte de l'eau à raison de 0,3 à 0,6 équivalents molaires; (ii) présente un spectre IR comportant des pics à 1757, 1331, 1290, 1211 et 767 cm?-1¿; (iii) présente un spectre de Raman comportant des pics à 1758, 1610, 1394, 1316 et 1289 cm?-¿1; (iv) présente un spectre de RMN à l'état solide comportant des déplacements chimiques (cf tableau I de la description; et (v) présente un motif de diffraction des rayons X par sa poudre (XRPD) (cf fig. IV de la description). L'invention porte également sur le procédé de préparation dudit sel, sur une préparation pharmaceutique le contenant et sur son utilisation et celle de ladite préparation en médecine.
Choudary Bernadette Marie
Lynch Ian Robert
Sasse Michael John
Gowling Lafleur Henderson Llp
Smithkline Beecham P.l.c.
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