C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/24 (2006.01) A61K 31/381 (2006.01) A61K 31/4436 (2006.01) A61P 3/10 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2597073
The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have glucagon receptor antagonist or inverse agonist activity, as well as methods of using these compounds and intermediates and methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
La présente invention concerne des nouveaux composés de formule (I) ou des sels associés acceptables pharmaceutiquement qui possèdent un antagoniste du récepteur du glucagon ou une activité agoniste inverse, ainsi que des méthodes d'utilisation de ces composés et intermédiaires et des méthodes de préparation de tels composés. Dans un autre mode de réalisation, cette invention a pour objet des compositions pharmaceutiques renfermant des composés de formule (I), ainsi que des méthodes les employant dans le traitement de troubles diabétiques et d'autres troubles métaboliques liés au glucagon, et similaire.
Chappell Mark Donald
Conner Scott Eugene
Tripp Allie Edward
Zhu Guoxin
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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