Substituted thiophenes with antibacterial activity

Details Substituted thiophenes with antibacterial activity Substituted thiophenes with antibacterial activity

C - Chemistry, Metallurgy

07

D

C07D 409/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/4709 (2006.01) A61K 31/519 (2006.01) A61P 31/04 (2006.01) C07D 333/28 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2517523

Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.

L'invention concerne de nouveaux thiophènes substitués, inhibiteurs de la méthionyl-t-RNA synthétase(MRS) bactérienne. L'invention concerne également une méthode de préparation de ceux-ci, et leur utilisation thérapeutique comme agents antibactériens.

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