Substituted triazoles as sodium channel blockers

Details Substituted triazoles as sodium channel blockers Substituted triazoles as sodium channel blockers

C - Chemistry, Metallurgy

07

D

C07D 249/10 (2006.01) A61K 31/4196 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2545254

Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III).

L'invention concerne des composés triazoles substitués représentés par les formules I, II ou III ou des sels de ceux-ci, acceptables au plan pharmaceutique. Ces compositions pharmaceutiques comprennent une quantité efficace desdits composés, seuls ou combinés à un ou plusieurs composés actifs au plan thérapeutique, et un véhicule acceptable au plan pharmaceutique. Des méthodes de traitement d'états associés à ou induits par l'activité du canal sodique, dont, entre autres, la douleur aiguë, la douleur chronique, la douleur viscérale, la douleur inflammatoire, la douleur neuropathique, la migraine, la céphalée, la migraine, l'épilepsie, le syndrome du côlon irritable, la neuropathie diabétique, la sclérose en plaque, la manie-dépression et le trouble bipolaire, consistent à administrer une quantité efficace desdits composés, seuls ou combinés à un ou plusieurs composés actifs au plan thérapeutique. Une méthode d'anesthésie locale consiste à administrer une dose efficace d'un composé de l'invention, seul ou combiné à un ou plusieurs composés actifs, et un véhicule acceptable au plan pharmaceutique.

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