C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/264
C07D 487/04 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01)
Patent
CA 2035499
This invention is directed to a group of compounds which are acyl derivatives of amino substituted triazolopyridazines. They are prepared by the reaction of an aminotriazolopyridazine or an aminotriazolophthalazine with an appropriate acid chloride. These compounds possess bronchodilating and anti-allergenic activity and are of the following general formula: Image wherein Image R7 and R8 are each independently H or CH3, or R7 and R8 together are -CH2CH2CH2CH2-; and when R7 and R8 are together -CH2CH2CH2CH2-, then, R3 is Image Image or -NH2 ; and when R7 and R8 are each independently H or CH3, then R3 is Image or Image -2-
Peet Norton P.
Sunder Shyam
Aventis Pharma Inc.
Merrell Dow Pharmaceuticals (canada) Inc.
Osler Hoskin & Harcourt Llp
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