C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61K 31/437 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2733671
The present invention relates to certain substituted tricyclic acid derivatives of Formula (I) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1- associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, myocardial ischemia-reperfusion injury injury, hypertensive nephropathy, glomerulosclerosis, gastritis, polymyositis, thyroiditis, vitiligo, hepatitis, biliary cirrhosis, microbial infections and associated diseases, viral infections and associated diseases, diseases and disorders mediated by lymphocytes, auto immune diseases, inflammatory diseases, and cancer.
L'invention concerne certains dérivés d'acides tricycliques substitués de Formule (I) et de sels pharmaceutiquement acceptables de ceux-ci, qui présentent des propriétés pharmacologiques utiles, par exemple en tant qu'agonistes du récepteur S1P1. L'invention concerne également des compositions pharmaceutiques contenant des composés selon l'invention, ainsi que des méthodes d'utilisation de ces composés et compositions dans le traitement des troubles liés à S1P1, par exemple le psoriasis, la polyarthrite rhumatoïde, la maladie de Crohn, le rejet de greffe, la sclérose en plaques, le lupus érythémateux systémique, la colite ulcéreuse, le diabète de type I, l'acné, la lésion d'ischémie-reperfusion myocardique, la néphropathie hypertensive, la glomérulosclérose, la gastrite, la polymyosite, la thyroïdite, le vitiligo, l'hépatite, la cirrhose biliaire, les infections microbiennes et maladies connexes, les infections virales et maladies connexes, les maladies et troubles induits par les lymphocytes, les maladies auto-immunes, les maladies inflammatoires et le cancer.
Buzard Daniel J.
Jones Robert M.
Kawasaki Andrew M.
Kim Sun Hee
Lehmann Juerg
Arena Pharmaceuticals Inc.
Smart & Biggar
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