Substituted tricyclic compounds as protein kinase inhibitors

Details Substituted tricyclic compounds as protein kinase inhibitors Substituted tricyclic compounds as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/517 (2006.01) C07D 239/94 (2006.01) C07D 405/12 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2542076

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure (I) including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from (II) and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

L'invention concerne des inhibiteurs de la protéine kinase utilisés dans le traitement des maladies et des états induits par la protéine kinase, tels que le cancer, ainsi que des stéréoisomères, des promédicaments et des sels pharmaceutiquement acceptables de ces composés. Les composés selon l'invention présentent la structure suivante : (I), dans laquelle A représente un groupe fonctionnel cyclique choisi entre (I-A), (I-B) ou (I-C), et R1, R2, R3, X, Z, L1, Cycl1, L2 et Cycl2 sont tels que définis dans la description. L'invention concerne également des compositions contenant un de ces composés, ainsi que des méthodes d'utilisation associées.

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