C - Chemistry – Metallurgy – 09 – B
Patent
C - Chemistry, Metallurgy
09
B
C09B 23/02 (2006.01) C07D 215/18 (2006.01) C07D 263/54 (2006.01) C07D 277/62 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2179284
The invention describes the preparation and use of fluorescent stains for nucleic acids derived from unsymmetrical cyanine dyes comprising a substituted benzazolium ring system linked by a methine bridge to a pyridinium or quinolinium ring system. The cyanine dyes of the invention possess a high sensitivity to oligonucleotides and larger nucleic acid polymers in a wide range of cells and gels, and are useful for the analysis of cell structure, membrane integrity or function, and determination of cell cycle distribution.
Préparation et utilisation de matières colorantes fluorescentes pour des acides nucléiques dérivées de colorants cyanine asymétriques comprenant un système cyclique benzazolium substitué lié par un pont méthine à un système cyclique pyridinium ou quinolinium. Les colorants cyanine de la présente invention possèdent une forte sensibilité aux oligonucléotides et aux polymères d'acides nucléiques plus grands dans une large gamme de cellules et de gels, et ils sont utiles pour l'analyse de la structure cellulaire, de l'intégrité ou de la fonction de membranes et de la détermination de la répartition du cycle cellulaire.
Haugland Richard P.
Jin Xiaokui
Jones Laurie J.
Millard Paul J.
Mozer Thomas J.
Mbm Intellectual Property Law Llp
Molecular Probes Inc.
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