Substituted urea derivatives for treating cardiac diseases

Details Substituted urea derivatives for treating cardiac diseases Substituted urea derivatives for treating cardiac diseases

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2570999

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

L'invention concerne certains dérivés d'urée substitués qui modulent de façon sélective le sarcomère cardiaque, par exemple par potentialisation de la myosine cardiaque, et sont utiles dans le traitement d'insuffisances cardiaques systoliques, notamment des insuffisances cardiaques congestives.

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