C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2180505
A substrate selective for detection of mammalian 5-C-DNA methyltransferase in the presence of bacterial 5-C-DNA methyltransferase, said substrate comprising oligomeric DNA which contains at least one 5-methylcytosine residue, and at least one cytosine or 5-fluorocytosine residue, each of which are followed in linkage to a guanine residue. The invention also includes a method for measuring the presence of mammalian 5-C-DNA methyltransferase which comprises contacting a sample containing 5-C-DNA methyl transferase with the substrate and also includes a method for inhibiting mammalian 5-C-DNA methyltransferase which comprises contacting a sample containing 5-C-DNA methyl transferase with the substrate.
Christman Judith K.
Marasco Canio J. Jr.
Sheikhnejad Gholamreza
Sufrin Janice R.
Christman Judith K.
Gowling Lafleur Henderson Llp
Health Research Inc.
Sheikhnejad Gholamreza
LandOfFree
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