C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/04 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2410898
The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a .beta.-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
La présente invention concerne de nouveaux substrats destinés à Hu-Asp, de manière plus particulière l'invention concerne des substrats peptidiques et des substrats de polypeptides hybrides comprenant un site de restriction de la .beta.-sécrétase; ainsi que des procédés et des compositions permettant de produire et d'utiliser lesdits peptides.
Bienkowski Michael Jerome
Emmons Thomas L.
Gurney Mark E.
Heinrikson Robert L.
Tomasselli Alfredo G.
Elan Pharmaceuticals Inc.
Macrae & Co.
Pharmacia & Upjohn Company
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