C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/81 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) A61K 38/00 (2006.01) C07D 207/16 (2006.01) C07D 211/04 (2006.01) C07D 277/06 (2006.01) C07D 401/00 (2006.01) C07D 409/00 (2006.01) C07K 7/06 (2006.01) G01N 33/53 (2006.01) C12N 9/64 (2006.01) C12N 9/68 (2006.01)
Patent
CA 2658331
The present invention is directed toward inhibitors of antiplasmin cleaving enzyme for use in various therapies related to fibrin and .alpha.2-antiplasmin, and to substrates of APCE, which may be used, for example, in screening methods for identifying such inhibitors. The present invention is further directed to methods of treating or inhibiting atherosclerosis and thrombus disorders by altering the rations of types of plasma .alpha.2-antiplasmin.
La présente invention concerne des inhibiteurs de l'enzyme de clivage de l'antiplasmine (ECAP) destinés à être utilisés dans diverses thérapies associées à la fibrine et à l'antiplasmine .alpha.2, ainsi que des substrats d'ECAP, qui peuvent être utilisés, par exemple, dans des procédés de criblage destinés à l'identification desdits inhibiteurs. La présente invention concerne en outre des procédés de traitement ou d'inhibition de l'athérosclérose et de troubles thrombotiques grâce à une modification des rapports des types d'antiplasmine .alpha.2 plasmatique.
Christiansen Victoria J.
Jackson Kenneth W.
Lee Kyung N.
Mckee Patrick A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Christiansen Victoria J.
Jackson Kenneth W.
Lee Kyung N.
Mckee Patrick A.
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