Substrates and inhibitors of proteolytic enzymes

Details Substrates and inhibitors of proteolytic enzymes Substrates and inhibitors of proteolytic enzymes

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) B01J 19/00 (2006.01) C07K 1/04 (2006.01) C07K 4/00 (2006.01) C07K 5/06 (2006.01) C07K 7/02 (2006.01) C07K 7/06 (2006.01) C12M 1/40 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2252508

The present invention relates to the field of compounds which are substrates or inhibitors of proteolytic enzymes and to apparatus and methods for identifying substrates or inhibitors for proteolytic enzymes. We have devised a combinatorial method for the rapid identification of binding motifs which will greatly expedite the synthesis of inhibitors of a variety of proteolytic enzymes such as aspartyl proteases, serine proteases, metallo proteases and cysteinyl proteases.

L'invention concerne le domaine des composés qui sont des substrats ou des inhibiteurs d'enzymes protéolytiques, ainsi que des dispositifs et des procédés permettant d'identifier des substrats ou des inhibiteurs d'enzymes protéolytiques. Nous avons inventé une méthode combinatoire permettant d'identifier rapidement des motifs de liaison, qui facilitera nettement la synthèse d'inhibiteurs d'une variété d'enzymes protéolytiques telles qu'aspartyl-protéases, sérine protéases, métalloprotéases et cystéinyl-protéases.

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