Substrates, compositions, elements and methods for the...

C - Chemistry – Metallurgy – 07 – D

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C07D 215/12 (2006.01) C07D 217/16 (2006.01) C09B 23/14 (2006.01) C12Q 1/48 (2006.01)

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CA 1269386

SUBSTRATES, COMPOSITIONS, ELEMENTS AND METHODS FOR THE DETERMINATION OF .gamma.-GLUTAMYLTRANSFERASE USING A .gamma. GLUTAMYL AMINOSTYRYLQUINOLINIUM Abstract New substrates for .gamma.-glutamyltransferase (.gamma.-GT) are disclosed. These substrates are useful in the colorimetric determination of .gamma.-GT since the cleavage of the .gamma.-glutamyl group produces a detect- able species- -an aminostyrylguinolinium dye. The substrates have the formula: Image wherein: R and R1 are independently selected from hydrogen, alkyl and alkoxy and Image or Image wherein: R2 is alkyl having from 1 to 4 carbon atoms; R3 and R4 are independently selected from hydrogen, alkyl, alkoxy, nitro, cyano and halogen; and X.THETA. is an anion.

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