C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/11, 530/5.04
C12Q 1/02 (2006.01) C07K 5/083 (2006.01) C07K 5/097 (2006.01) C12Q 1/34 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 1129847
ABSTRACT OF THE DISCLOSURE Novel substrates are provided for angiotensin converting enzymes which make it possible for the first time to assay the enzyme by measuring the radioactivity of the remnant product resulting from enzymatic hydrolysis of the penultimate peptide bond at the carboxy terminal end of the peptide substrate. The remnant product may be extracted nearly quantitatively from serum by an aprotic organic solvent while the non-hydrolyzed substrate is only slightly, if at all. The substrates particularly are tri- and tetra- peptides having radioactively labelled aromatic substituents at the terminal amino group, three such substrates being 3H-HisGlyGly, 125I-HPPGlyGlyGly and 3H-benzoylProPheArg.
302876
Chung Alfred
Ryan James W.
Sim & Mcburney
Ventrex Laboratories Inc.
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