A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 11/04 (2006.01)
Patent
CA 2534566
An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate (12) with an oxidation resistant exterior surface (14) and a drug composition film (18) on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.
L'invention concerne un ensemble et un procédé de production d'un aérosol par condensation. L'ensemble comprend un substrat métallique thermoconducteur (12) présentant une surface extérieure résistante à l'oxydation (14) et une couche mince de composition médicamenteuse (18) sur la surface extérieure de la surface, ledit ensemble étant destiné à être utilisé dans un dispositif aérosol. L'épaisseur de la couche mince et de la surface du substrat est telle que l'aérosol formé par vaporisation et condensation de la composition médicamenteuse contient 10 % en poids ou moins de produits de dégradation de médicaments et au moins 50 % de la quantité totale de la composition médicamenteuse dans la couche mince. Les procédés de traitement de la surface extérieure font appel à un traitement thermique et chimique et à la formation d'une couche de finition protectrice.
Bennett Bryson
Hale Ron L.
Lu Amy T.
Myers Daniel J.
Rabinowitz Joshua D.
Alexza Pharmaceuticals Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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