Substrates_for the inhibition of cell or tissue growth

Details Substrates_for the inhibition of cell or tissue growth Substrates_for the inhibition of cell or tissue growth

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61L 15/24 (2006.01) A61L 15/42 (2006.01) A61L 27/34 (2006.01) A61L 27/50 (2006.01) B05D 5/00 (2006.01)

Patent

CA 2449586

The present invention relates to novel substrates, to methods of making them and to uses therefor. The substrates of the invention comprise a base portion and a surface layer covering at least part of the base portion, with a binding layer provided therebetween. The surface layer provides, on at least a part of the substrate, topographical features having at least one nano scale dimension. These topographical features are adapted to facilitate, influence, control or inhibit cell or tissue growth thereon and/or therebetween and the substrate may be used for the study, manipulation or modification of at least one cellular or tissue behaviour or response.

L'invention concerne de nouveaux substrats, des procédés de fabrication de ces substrats, et leurs utilisations. Les substrats de l'invention comprennent une partie de base et une couche de surface couvrant au moins une partie de la partie de base, une couche de liaison étant située entre les deux éléments susmentionnés. La couche de surface présente, sur au moins une partie du substrat, des caractéristiques topographiques présentant au moins une dimension à l'échelle du nanomètre. Ces caractéristiques topographiques sont conçues pour faciliter, influencer, commander ou inhiber la croissance cellulaire ou tissulaire sur ledit substrat, et/ou entre les éléments dudit substrat. Le substrat peut être utilisé pour l'étude, la manipulation, ou la modification au moins d'un comportement ou d'une réponse cellulaire ou tissulaire.

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