Subtilin variant of enhanced stability and activity

Details Subtilin variant of enhanced stability and activity Subtilin variant of enhanced stability and activity

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07K 14/32 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2150025

A subtilin mutant substituting isoleucine for Glu4 of the native sequence exhibits a 57-fold improvement in stability, resisting modification of the dehydroalanine residue at position 5. This stable mutant exhibits 3-4 times the specific activity, in suppression of bacterial spore outgrowth of the native bacteriocin. A method for site-specific mutagenesis as well as the resulting mutant gene, plasmid and and transformamt is similarly set forth.

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