C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/7088 (2006.01) A61K 39/07 (2006.01) A61K 48/00 (2006.01) C07K 14/32 (2006.01) C11D 3/386 (2006.01) C12N 9/54 (2006.01) C12N 9/56 (2006.01) C12N 15/32 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2476890
The present invention provides methods for the identification of CD4+ T-cell epitopes in subtilisin Carlsberg proteins. The present invention also provides for the production of altered peptides which, when incorporated into a wild- type subtilisin Carlsberg protein produce an altered immunogenic response, preferably a low immunogenic response in humans. In particular, the present invention provides means, including methods and compositions suitable for reducing the immunogenicity of ALCALASE® enzyme.
La présente invention concerne des méthodes d'identification d'épitopes des lymphocytes T dans les protéines de la subtilisine (Carlsberg). Elle concerne également la production de peptides modifiés qui, lorsqu'ils sont incorporés dans une protéine de la subtilisine (Carlsberg), produisent une réponse immunogène modifiée, de préférence une faible réponse immunogène chez l'homme. L'invention concerne en particulier des moyens, y compris des méthodes et des compositions, qui peuvent réduire de manière appropriée l'antigénicité de l'enzyme ALCALASE®.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Genencor International Inc.
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