Subunit respiratory syncytial virus vaccine preparation

Details Subunit respiratory syncytial virus vaccine preparation Subunit respiratory syncytial virus vaccine preparation

C - Chemistry, Metallurgy

07

K

C07K 14/135 (2006.01) A61K 39/155 (2006.01) C07K 1/14 (2006.01) C07K 16/10 (2006.01) C12N 7/00 (2006.01) C12N 7/02 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2259594

The fusion (F) protein, attachment (G) protein and matrix (M) protein of respiratory syncytial virus (RSV) are isolated and purified from respiratory syncytial virus by mild detergent extraction of the proteins from concentrated virus, loading the protein onto a hydroxyapatide or other ion-exchange matrix column and eluting the protein using mild salt treatment. The F, G and M proteins, formulated as immunogenic compositions, are safe and highly immunogenic and protect relevant animal models against disease caused by respiratory syncytial virus infection.

Protéines de fusion (F), de liaison (G) et de matrice (M) de virus syncytial respiratoire (RSV) qui sont isolées et purifiées à partir du virus syncytial respiratoire par extraction au détergent doux des protéines du virus concentré. Le procédé consiste à charger la protéine sur une colonne d'hydroxyapatite ou autre colonne à matrice échangeuse d'ions et à éluer la protéine à l'aide d'un traitement doux au sel. Lesdites protéines F, G et M, formulées sous forme de compositions immunogènes, sont sûres et hautement immunogènes et protègent des modèles animaux pertinents contre la maladie due à l'infection causée par le virus syncytial respiratoire.

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